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Covid-19 vaccines: What are clinical trials and how do they work?

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Pfizer and BioNtech, the other by Moderna and the US National Institutes of Health -- are about 95 percent effective.Here's a look at how trials work:Who leads clinical trials? American pharmaceutical Pfizer itself has led and financed a clinical trial of its vaccine involving almost 44,000 people in the United States, Germany, Turkey, South Africa, Brazil and Argentina.Volunteers who are accepted receive two doses 21 days apart and get regular follow-up.The Moderna-NIH vaccine is given 28-days-apart at locations across the US on some 30,000 volunteers, in a trial part funded by the taxpayer.The trials are "blinded" meaning neither the volunteers nor the health care providers know who gets the medicine and who gets a saline solution.

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