74-Day BoutSome of the first deletions were seen in an immunocompromised cancer patient treated at the University of Pittsburgh Medical Center who died after a 74-day bout with Covid-19.
In that time, multiple immune-escaping deletions developed, according to the University of Pittsburgh’s Duprex, who reported on the cancer patient’s deletions in November.“If the damn thing is gone you are not going to be able to fix it," Duprex said.What makes SARS-CoV-2’s future so hard to predict is that viral evolution is like a three dimensional chess game.
It’s not just the individual mutations that matter, but also the order and combinations in which they occur. A single mutation may alter the virus in subtle ways that change the impact of others.