Manchester City face Arsenal at the Etihad just hours later. While United will kick-off their campaign a few days later away at Tottenham as Ole Gunnar Solskjaer's side look to maintain their bid for a top-four finish.
However, all games will take place behind closed doors and a number of safety measures have been put in place due to the current coronavirus pandemic.And below is a look at the measures that have been put in place and what fans can expect to see when watching their side in action.
Although most clubs in the top-flight operate with a high number of staff on a matchday, the Premier League is hoping that only essential staff will be present for games.