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Scientists see downsides to top COVID-19 vaccines from Russia, China

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www.livemint.com

TORONTO/CHICAGO : High-profile COVID-19 vaccines developed in Russia and China share a potential shortcoming: They are based on a common cold virus that many people have been exposed to, potentially limiting their effectiveness, some experts say.CanSino Biologics' vaccine, approved for military use in China, is a modified form of adenovirus type 5, or Ad5.

The company is in talks to get emergency approval in several countries before completing large-scale trials, the Wall Street Journal reported last week.A vaccine developed by Moscow's Gamaleya Institute, approved in Russia earlier this month despite limited testing, is based on Ad5 and a second less common adenovirus."The Ad5 concerns me just because a lot of people have immunity," said.

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