WASHINGTON (AP) - Marking a year of loss and disruption, President Joe Biden will use his first prime-time address since taking office to steer the nation toward a hungered-for sentiment — hope — in the "next phase" of the fight against the pandemic that has killed more than 529,000 Americans.Previewing his remarks, Biden said he would "talk about what we’ve been through as a nation this past year, but more importantly, I’m going to talk about what comes next."Biden's challenge Thursday night will be to honor the sacrifices made by Americans over the last year while encouraging them to remain vigilant despite "virus fatigue" and growing impatience to resume normal activities given the tantalizing promise of vaccines.