Jocelyn KaiserScience’s COVID-19 reporting is supported by the Pulitzer Center and the Heising-Simons Foundation.It’s one of the pandemic’s puzzles: Most people infected by SARS-CoV-2 never feel sick, whereas others develop severe disease or even end up in an intensive care unit clinging to life.
Age and preexisting conditions, such as obesity, account for much of the disparity. But geneticists have raced to see whether a person’s DNA also explains why some get hit hard by the coronavirus, and they have uncovered tantalizing leads.Now, a U.K.
group studying more than 2200 COVID-19 patients has pinned down common gene variants that are linked to the most severe cases of the disease, and that point to existing drugs that could be repurposed.