COVID-19 breakthrough cases confer 'super immunity,' study findsCOVID-19 breakthrough infections in fully vaccinated US adults substantially boosted humoral immunity and demonstrated cross-neutralization against the Delta (B1617.2) variant, despite mostly mild illness, finds a small study yesterday in JAMA.Humoral immunity involves antibodies secreted by B cells circulating in bodily fluids.Oregon Health & Science University researchers recruited 26 fully vaccinated healthcare workers diagnosed as having COVID-19 breakthrough infections and an equal number of matched controls from Jan 31 to Aug 18, 2021.
They also sequenced the viral genomes to determine the causative variants.Average patient age was 38 years, 77% were women, 92% had