Sorrento Therapeutics has reported that its Covid-19 therapeutic antibody candidate, STI-1499, can completely block the viral infection in-vitro during preclinical studies.

The company intends to develop an antibody cocktail that would protect from Covid-19 and remain effective even if mutations make a single antibody less effective over time.

Sorrento has been diligently screening numerous antibodies in its G-MAB fully human antibody library and discovered hundreds of candidates that bind the S1 subunit of the SARS-CoV-2 Spike protein.

Of these antibodies, around 12 showed the ability to inhibit the interaction of the S1 protein with human angiotensin-converting enzyme 2 (ACE2) used for viral entrance into human cells.

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United States	Cases: 46 252 513 Deaths: 750 423 Recovered: 0
India	Cases: 34 321 025 Deaths: 459 652 Recovered: 0
Brazil	Cases: 21 835 785 Deaths: 608 235 Recovered: 0
United Kingdom	Cases: 9 215 683 Deaths: 141 607 Recovered: 0
Russia	Cases: 8 494 589 Deaths: 237 619 Recovered: 0

Sorrento’s antibody completely blocks Covid-19 in-vitro

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