WASHINGTON : Will COVID-19 vaccines work if I have a weak immune system? Probably not as well as they do in healthy people, but the shots should offer some protection.
It's why vaccinations are still recommended for people with immune systems weakened by disease or certain medications. It's also important that your family, friends and caregivers get vaccinated, which will make it far less likely that they pass on the virus.
About 3% of US adults have weakened immune systems. Among them are people with HIV or AIDS, transplant recipients, some cancer patients and people with autoimmune disorders such as rheumatoid arthritis, inflammatory bowel disease and lupus.