Scientists have known for some time that restricting calorie intake in laboratory animals can extend their lifespan and reduce their risk of developing diseases of older age, such as cancer, heart disease, diabetes, and Alzheimer’s disease.Some studies suggest that calorie restriction may have health benefits for humans, too.
However, achieving and maintaining a calorie restricted diet is challenging for the vast majority of people.Identifying a drug that can mimic the metabolic effects of calorie restriction has, therefore, been an important goal of research into life extension.One of the striking effects of calorie restriction is that it leads to a fall in core body temperature.