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COVID booster adds substantial protection against Omicron hospitalization

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Three doses of an mRNA COVID-19 vaccine during a time of Omicron variant predominance were tied to a 59% lower odds of hospitalization than two doses, although protection waned over time, finds a US case-control study published late last week in JAMA.A team led by a University of Chicago researcher used electronic health record data to estimate the odds of COVID-related hospitalization after the receipt of only the primary vaccination series (two doses) or a third (booster) dose of an mRNA vaccine among adults admitted to hospitals in the Providence Health & Services network in one of six Western states from Oct 1, 2021, to Jul 26, 2022.

During the study period, 81% of cases were attributed to the Omicron variant.Each of the 3,062 COVID-19 patients were matched 1:4 with 12,248 control patients admitted to the hospital for non-COVID indications within 3 days of the case-patient in the same geographic region and received a second vaccine dose (Pfizer/BioNTech or Moderna) within 7 days of the case-patient.

Average age was 70.8 years in case-patients and 67.1 in controls, and proportions of men were 52.6% and 46.7%, respectively.Protection waned after 4 or 5 monthsA multivariable analysis showed an association between a third dose and reduced odds of COVID-19 hospitalization (34.7% of case-patients vs 49.3% of controls; adjusted odds ratio [aOR], 0.41, or a 59% reduction).

The odds of hospitalization depended on time since the third dose (aOR at less than 50 days, 0.24; 50 to 100 days, 0.24; 101 to 150 days, 0.47; and after 150 days, 0.72).The researchers noted that studies comparing COVID-19 rates among recipients of a booster dose and their unvaccinated counterparts have found 55% to 99% lower odds of COVID-19 among those

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NEW YORK, NEW YORK - AUGUST 25: A New York University (NYU) flag flies outside a Covid-19 test tent outside of the NYU business school on August 25, 2020 in New York City. All students arriving back to the campus are required to get tested for the vi NEW YORK - Maitland Jones Jr., a chemistry professor at New York University who also taught for four decades at Princeton, was fired in August after undergraduate students circulated a petition complaining that his course was too difficult. Dozens of the college students, many of them aspiring doctors, signed on to the petition in the spring. "We are very concerned about our scores, and find that they are not an accurate reflection of the time and effort put into this class," the petition read, according to the New York Times. "We urge you to realize… that a class with such a high percentage of withdrawals and low grades has failed to make students’ learning and well-being a priority and reflects poorly on the chemistry department as well as the institution as a whole."Jones, 84, told the New York Times that he started seeing a loss of focus among students about a decade ago, but the problem was exacerbated by the coronavirus pandemic in 2020. "They weren’t coming to class, that’s for sure, because I can count the house," Jones told the newspaper.
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