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Mouse brains seen in unprecedented 3D detail, thanks to new staining technique
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By Dennis NormileScientists studying brains and other organs and cancerous tumors have long tried to get detailed 3D views of their insides—down to the level of blood vessel and cell type.
But producing such images is time-consuming and difficult. Now, dramatic improvements to a 3D imaging technique can reveal the internal components of entire organs or even animals in a simple procedure, researchers report this week.
The new tissue staining protocol allows cellular level analyses in unprecedented detail; it could aid research efforts in neuroscience, developmental and evolutionary biology, and immunology, and it could prove useful in diagnosing some cancers and studying damaged brain tissue after death.To image biological samples in 3D,
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