Many deaths are feared after a plane carrying 107 passengers and crew crashed into houses and exploded into flames after the captain reported an engine failure and declared a mayday.
The Pakistan International Airlines (PIA) jet was on its final approach to Karachi's main airport when it went down in a residential area near Model Colony about a minute before it was due to land.
As many as 30 people were pulled out of the rubble and the body of a five-year-old child was recovered from the site, local media reported.
Footage shows an apocalyptic scene with fires burning in a narrow and heavily populated street that was filled with debris from the wrecked Airbus A320 as well as buildings that were damaged and cars that were totalled.