16 in every 100,000 males in the United States are born with DMD. Females who have one altered gene are carriers. While most female carriers have no signs or symptoms of the condition, they may experience some mild signs or symptoms in rare cases.The muscle wastage of DMD causes difficulty walking and speaking, and eventually, breathing.
There is currently no cure for the disease, and patients with DMD have an average life expectancy of just 26 years old.A mutation in the dystrophin gene, which is important for maintaining muscle fibers, causes DMD.
Muscle fibers in people with DMD are highly susceptible to injury and are also unable to regenerate. Fibrotic (scar) tissue replaces the fibers.There is also a role for an enzyme called MKP5,.
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