The President and the Taoiseach will discuss proposals for a new international pandemic treaty with the head of the World Health Organization in Dublin.
The WHO's 194 member states set up a process to draft a treaty on pandemic preparedness and response in light of the impact of Covid-19.
However, critics say such a treaty would be a threat to national sovereignty. WHO Director General Dr Tedros Adhanom Ghebreyesus and Executive Director Dr Mike Ryan will discuss the proposals with President Michael D Higgins and Leo Varadkar.
Speaking on RTÉ's Morning Ireland, Dr Ryan said there is nothing in the drafts of the treaty "that in any way compromise the sovereignty of countries", and called for a healthy debate on the issue. "Effectively what we are looking at here is a collective agreement to say 'how are we going to manage the next pandemic?' "How are we going to be ready?