A study combining analysis of patient samples with mice studies has identified new drug targets for alcohol-related liver disease, which, currently, doctors can only treat by transplant.
Alcohol-related liver disease (ALD), as its name suggests, is damage to the liver that the excessive consumption of alcohol causes.
Over time, excessive alcohol consumption can cause inflammation and scarring (fibrosis) of liver tissue, and may eventually lead to liver failure.
According to an analysis of trends published in the World Journal of Hepatology in 2017, 16.5% of all liver transplants between 2002–2015 occurred as a result of ALD, making the disease the third most common reason for transplantation.