Contrary to early reports, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen is not associated with severe COVID-19 disease or death, according to a cohort study published yesterday in PLOS One.Researchers analyzed data from all 9,236 Danish residents who tested positive for SARS-CoV-2, the virus that causes COVID-19, from Feb 27 to Apr 29, of whom 248 (2.7%) had filled a prescription for an NSAID in the 30 days before their diagnosis.
In Denmark, a prescription is needed for obtaining NSAIDs, except for low-dose (200-milligram) ibuprofen.Relative risks among users, nonusersThere were no significant differences between NSAID users and non-users in terms of 30-day death rate (6.3% of NSAID users vs 6.1% of