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Rare mutations reveal more about COVID-19 and the immune system

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Alexander Hoischen, a geneticist at Radboud University Medical Center (RUMC) in Nijmegen. “It may be a mere coincidence that two brothers from the same family become so severely ill,” Hoischen adds. “But it is also possible that an inborn error of the immune system has played an important role.”Hoischen and his colleagues were investigating this possibility when they discovered two more brothers with COVID-19 on ventilators at intensive care units elsewhere in the region.

Both individuals were also under 35 years old and previously healthy.Doctors had admitted the four males, from two unrelated families to intensive care units early in the outbreak in March and April 2020.Only three out of the four individuals survived the infection.

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