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Study suggests BA.2 COVID-19 subvariant more contagious

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A study on how Omicron subvariants transmit in Danish households found that the BA.2 subvariant is substantially more transmissible than the original variant, researchers reported yesterday in preprint findings.BA.2 is now dominant in Denmark, with levels rising in other countries, raising questions about how fast current surges will decline.

In South Africa, which first reported the original Omicron variant, BA.2 levels are increasing, but against the backdrop of decreasing infections, Tulio de Oliveira, PhD, who directs South Africa's Centre for Epidemic Response and Innovation, said yesterday.Less transmission from breakthrough casesThe group examined secondary attack rates in households that had a primary case between Dec 20, 2021, and Jan 11, looking at differences in transmission between BA.2, BA.1 (the original Omicron variant), unknown, and Delta variants.

Of the households, 2,122 had an initial BA.2 case, and 6,419 had a primary BA.1 case.They found that the secondary attack rate was substantially higher for BA.2 than BA.1, estimating that the rate was 39% for BA.2 and 29% for BA.1.When the team looked at susceptibility differences, they found that BA.2 was associated with increased susceptibility in unvaccinated people, fully vaccinated people, and those who had received boosters compared with BA.1.

They also found that unvaccinated primary cases involving BA.2 were more likely to transmit the virus, compared to those who had the original strain.

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