Over 40% of COVID patient stool samples had viral RNA but no live virusOver 40% of 79 stool samples from COVID-19 patients admitted to one of four hospitals in Spain contained SARS-CoV-2 RNA but no live virus, suggesting a negligible ability to replicate in this medium and a very low likelihood of fecal-oral viral transmission, finds a study published yesterday in Scientific Reports.Researchers from the University of Seville collected stool samples from 62 adult COVID-19 patients at hospital admission and/or follow-up at up to 4 months from March 2020 to February 2021.
Median patient age was 59 years, 61.2% were men, and 30.6% had chronic conditions, the most common of which was solid-organ transplant (73.6%).The team detected SARS-CoV-2 genetic material in 27 of 62 patients (43.5%).
In the first week after illness onset, 7 of 19 (36.8%) patients excreted fecal viral RNA, compared with 9 of 28 (32.1%) in the second week.
A subset of patients, mostly solid-organ transplant recipients, excreted RNA until week 16. There were no differences by age, sex, or chronic conditions in the presence or absence of viral RNA in stool samples.