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Novartis and Incyte to trial Jakavi for Covid-19

Usa Switzerland covid-19 pneumonia infection patient
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Novartis, in alliance with Incyte, has announced plans to evaluate Jakavi (ruxolitinib) in a Phase III clinical trial to treat cytokine storm in patients with severe Covid-19 pneumonia.

Cytokine storm is a severe immune overreaction to infection and leads to deadly respiratory complications in Covid-19 patients.

Jakavi is an oral, JAK 1 and JAK 2 tyrosine kinase inhibitor. It is approved in Europe to treat adults with polycythemia vera (PV) and symptoms caused by primary myelofibrosis (MF), post-polycythemia vera MF, or post-essential thrombocythemia MF.

Novartis licensed Jakavi from Incyte in 2009; the Swiss pharma giant has rights to develop and commercialise the drug in certain indications outside the US.

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COVID-19
United States
United States
Cases: 46 252 513
Deaths: 750 423
Recovered: 0
India
India
Cases: 34 321 025
Deaths: 459 652
Recovered: 0
Brazil
Brazil
Cases: 21 835 785
Deaths: 608 235
Recovered: 0
United Kingdom
United Kingdom
Cases: 9 215 683
Deaths: 141 607
Recovered: 0
Russia
Russia
Cases: 8 494 589
Deaths: 237 619
Recovered: 0
Detail statistic
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