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Should you mix and match COVID-19 vaccines? Scientists are seeking answers

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www.sciencemag.org

Jon CohenScience’s COVID-19 reporting is supported by the Heising-Simons Foundation.With nine vaccines now showing they can powerfully prevent severe illness and death from COVID-19—and vaccines in short supply—researchers are mulling an issue that, even a few months ago, was only hypothetical: Should people mix and match vaccines that require two shots?If some combinations work, they may provide needed flexibility whenever production of a vaccine falters, as often happens.

And there’s even a chance that mixing doses of two different vaccines may boost the protection against COVID-19.One mixed vaccine trial is already underway: It is examining matching a dose of the Sputnik V vaccine made by Russia’s Gamaleya Research Institute of.

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