The inexpensive antidepressant fluvoxamine reduced the need for a long emergency department (ED) observation or a hospital stay among high-risk, symptomatic COVID-19 outpatients treated within 7 days of symptom onset as much as 30% to 65%, finds a Brazilian platform clinical trial yesterday in The Lancet Global Health.In the largest such trial to date, a team led by researchers in Brazil, the United States, and Canada randomly assigned 1,497 adult COVID-19 patients, most of them unvaccinated, in 11 cities to either 100 milligrams of fluvoxamine twice daily for 10 days or a placebo from Jan 20 to Aug 5, 2021.Average patient age was 50 years, 58% were female, 95% were of mixed race, and all had at least one predisposing medical condition.