Boston: One of the human body's main defences against viral infections may be helping the novel coronavirus infect more cells, according to a study which can help understand why some people are more susceptible than others to COVID-19.
The study, published in the journal Cell, used single-cell RNA sequencing, which identifies which of roughly 20,000 genes are "on" in individual cells, and found that only a tiny percentage of human respiratory and intestinal cells make the proteins that help the virus gain entry into human cells. "We started to look at cells from tissues such as the lining of the nasal cavity, the lungs, and gut, based on reported symptoms and where the virus has been detected," said Jose Ordovas-Montanes, study co-author