Mental decline seen in older COVID patients 1 year later
Cognitive impairment was more common among COVID-19 patients 60 years and older—particularly those with severe illness—released from hospitals in Wuhan, China, than among their uninfected peers, according to a 1-year follow-up study yesterday in JAMA Neurology.A team led by researchers at Daping Hospital in Chongqing, China, followed 1,438 COVID-19 survivors aged 60 and older released from one of three dedicated COVID-19 hospitals in Wuhan from Feb 10 to Apr 10, 2020, and compared them with 438 of their uninfected spouses.Because pre-COVID cognitive status wasn't available, family members provided their perceptions of cognitive changes using the Chinese version of the short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE).
The questionnaire contains 16 items that rate changes in memory and other domains, with decline defined as an item score of 3.5 or higher.
Trained raters interviewed COVID-19 patients at 12 months over the phone to evaluate cognition using the Chinese version of Telephone Interview of Cognitive Status-40 (TICS-40), which includes 10 variables and has a maximum of 40 points.
A score of 20 or lower was considered indicative of mild cognitive impairment (MCI), while a score of 12 or lower indicated dementia, and a decrease of 3 points or more was considered clinically meaningful cognitive decline.Of the COVID-19 patients.
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