Two studies published yesterday in the Journal of the Pediatric Infectious Diseases Society describe the presentation of the COVID-19–related multisystem inflammatory syndrome in children (MIS-C) and how heavy coronavirus exposure didn't lead to infection in four siblings aged 9 to 12 years.In addition, an expert review in the same journal recommends best practices for the use of antiviral drugs in infected children.Severe signs and symptoms, aggressive therapiesIn the first study, researchers at Temple University in Philadelphia conducted a systematic review and meta-analysis of 16 case reports and series involving 505 children with MIS-C from Jun 3 to Jul 23.