COVID-19 booster shot this fall -- and exactly how best to update it to fight a virus that surely will change even more by then."That’s the problem -- we’re being asked to more or less have a crystal ball today," said Dr.
Arnold Monto of the University of Michigan, who heads the Food and Drug Administration’s vaccine advisory committee.Current COVID-19 vaccines have saved millions of lives globally and those used in the U.S.
still offer strong protection against hospitalization and death -- especially after a booster dose. But their ability to block infection markedly dropped when the super-contagious omicron mutant emerged.Pfizer and Moderna tested shots updated to better match the omicron that surged over the winter, but that first mutant has disappeared -- replaced by its genetically distinct relatives.
The two newest omicron cousins, called BA.4 and BA.5, now make up about half of U.S. cases, according to the Centers for Disease Control and Prevention.That makes for a tough decision on how to tweak the shot recipe, and "our goal is to have the best possible match" to blunt an expected COVID-19 surge this fall and winter, FDA vaccine chief Dr.