In September 1918, still in the throes of World War One, Britain's Prime Minister David Lloyd George travelled to Manchester for a ceremonial visit.
Crowds of people gathered in Albert Square and lined the streets to see him receive the keys to the city. But within hours of the prime minister's visit to his birthplace, he was struck down with a deadly virus which ultimately killed around 50 million people worldwide.
He had caught Spanish flu - a pandemic which has been described as the most deadly to have been recorded in recent history. It infected around 500 million people globally - about a quarter of the world's population.