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Study: Serotonin Dysregulation Is the Common Denominator in Most ADHD Comorbidities - additudemag.com
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Study: Serotonin Dysregulation Is the Common Denominator in Most ADHD Comorbidities
August 13, 2025Serotonin dysfunction occurs in nearly three-quarters of psychiatric and somatic comorbidities linked to ADHD, according to a new systematic review published in Neuroscience & Biobehavioral Reviews.1The study identified 182 comorbidities in ADHD populations and found strong evidence linking 135 (74.2%) of them, including 91 psychiatric and 44 somatic conditions, to imbalances in the brain’s serotonergic system.“This association confirmed the occurrence of comorbidities within a clearly defined ADHD population (rather than the presence of ADHD within a population with a particular condition), and also confirmed that the comorbidity was a co-occurring condition and not an adverse event elicited by ADHD treatment,” the researchers wrote.The research team examined close to 50,000 papers published between January 2010 and March 2024. Based on the volume of articles and the overall high grade of evidence, they concluded that the top five psychiatric ADHD comorbidities associated with serotonin dysregulation include:The top five somatic ADHD comorbidities associated with a serotonin dysregulation include:The brain’s “feel good” chemical, serotonin is a neurotransmitter that helps regulate mood, impulsivity, and physical functions, such as sleep and digestion.According to a recent study in Nature, serotonin neurons signal to the brain the expected value of near-future rewards.
ADHD-Obesity Link Weakens in Big Cities: New Research - additudemag.com - New York - Usa - Italy - city Big
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ADHD-Obesity Link Weakens in Big Cities: New Research
May 27, 2025ADHD raises the risk of obesity, but its effect is dampened for people living in large cities, according to two new studies.Young adults with combined-type ADHD are more likely than their non-ADHD peers to carry excess weight around their midsection and to have an unhealthy waist-to-height ratio (known as the body mass index or BMI), according to a new cross-sectional study published in American Journal of Human Biology. 1Obesity-related health conditions, such as heart disease and Type 2 diabetes, are tied to excess abdominal fat.“The effect of ADHD on obesity intensified with age,” however, “no significant association was found with blood pressure, but trends suggested hypertension may escalate with age among ADHD individuals,” the study’s authors wrote.The biological link between ADHD and obesity, and the influence of environment on this relationship, was the focus of another new study led by researchers from the Tandon School of Engineering at New York University and the Italian National Institute of Health. 2The study, published in PLOS Complex Systems, proposed that ADHD influences obesity along two pathways:“A lot of people I work with complain about using food for stimulation,” said Nicole DeMasi Malcher, M.S., R.D., CDES, during the ADDitude webinar “Eating with ADHD: Improving Your Relationship with Food.” “They are constantly looking for food to deliver a quick fix rather than thinking about the long-term effects.”Malcher attributes this behavior, in part, to poor interoception, the ability to sense what’s happening inside the body, including cues such as thirst, hunger, and fullness.
Study: Vitamin D Insufficiency Worsens Sleep Problems in Children with ADHD - additudemag.com - state Oregon - county Frontier
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Study: Vitamin D Insufficiency Worsens Sleep Problems in Children with ADHD
April 29, 2025Vitamin D insufficiency worsens sleep problems in children with ADHD, but it does not directly affect the condition’s symptoms or functional impairments, a recent study published in Frontiers in Psychology found.1Children with ADHD are more likely to experience vitamin D deficiencies than are children without ADHD, according to previous research.2 However, this study found no causal relationship or direct link between ADHD symptoms and vitamin D insufficiency.Scientists did find that low vitamin D levels (below 30 ng/mL) can worsen sleep difficulties, impairing sleep quality and worsening sleep disordered breathing, in children with ADHD.The researchers wrote that sleep difficulties “increased daytime sleepiness, inattention, and oppositional defiant disorder symptoms in children.” Additionally, it was found that sleep disordered breathing can affect a child’s attention, focus, hyperactivity, memory, and executive functioning, essentially exacerbating ADHD symptoms.Nearly three-quarters of children with ADHD experience a sleep problem or disorder.3 Additionally, up to half of children with ADHD have sleep problems, such as difficulty sleeping, insomnia, night waking, and hypersomnia.4, 5This is the first study, to the researchers’ knowledge, that examines whether vitamin D insufficiency exacerbates sleep problems and symptoms in children with ADHD.
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