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PMDD, Autism, and ADHD: The Hushed Comorbidity

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Premenstrual Dysphoric Disorder (PMDD) is a hormonal health condition that causes clinically significant and impairing depression, anxiety, mood swings, and uncomfortable physical symptoms in the week leading up to menses, the onset of a period.

PMDD symptoms improve following menses and are minimal, if not absent, in the weeks following. PMDD disproportionately affects people with autism and ADHD.

Various medications can help control PMDD symptoms1.A patient meets the diagnostic criteria for PMDD if at least five of the following symptoms are met, including at least one from each category.

The symptoms must cause distress or interfere with activities of daily living during most menstrual cycles over the preceding year:While PMDD shares symptoms with premenstrual syndrome (PMS), PMDD is less common and more severe.

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February 18, 2025The Trump administration’s recently established Make America Healthy Again Commission has come under fire from medical experts and patient advocacy groups for singling out autism spectrum disorder and ADHD, saying the “over-utilization of medication” for those and other conditions “pose a dire threat to the American people and our way of life.” The commission, which will be chaired by the newly confirmed director of Health and Human Services, Robert F. Kennedy, Jr., a vocal anti-vaccine advocate, says it aims to end ADHD, autism, and other chronic health conditions with “fresh thinking on nutrition, physical activity, healthy lifestyles, over-reliance on medication and treatments, the effects of new technological habits, environmental impacts, and food and drug quality and safety.”Almost immediately, the American Psychiatric Association (APA) and Autistic Self Advocacy Network (ASAN) condemned what it called the stigmatizing language and stated purpose of the commission, which established a 100-day mission to:“We know from the evidence and from our own clinical practice that the psychiatric drugs mentioned in the order, when prescribed and used as directed by properly trained psychiatrists, are safe, effective, and in some cases, lifesaving,” wrote APA CEO and Medical Director Marketa M.
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