A study by Tim Wilens, M.D., and colleagues followed children and teens who were treated for ADHD with the non-stimulant medication atomoxetine, a selective norepinephrine reuptake inhibitor (SNRI).
The children’s symptoms significantly improved; their ADHD rating scale scores dropped from a 34 to a 21. However, 21 is still quite a high level of symptoms.
I want all symptoms on the ADHD rating scale to be mild or minimal, on average, which means achieving a score under 18.So, the researchers added OROS methylphenidate to the atomoxetine, and the subjects’ ADHD symptoms dropped almost by half to 12.
At this point, there was very little functional impairment from the ADHD symptoms: all 18 symptoms were either mild or undetectable.